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Compared with mouse thymocytes, mouse ES cells include higher levels of whole genomic H3K4me3 and have higher H3K4me3 occupancy on the promoter of the [pluripotent gene](http://oa.sccehui.com6101/chantalstclair/kristin1981/wiki/Coodes-Expands-Conveyancing-Staff) Oct4 46 In settlement with this, global decreases in H3K4me3 levels occur during retinoic acid (RA)-induced differentiation of mouse ES cells 47 In addition, there are dynamic adjustments in H3K4me3 profiles at particular sets of genes during ES cell differentiation. |
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