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+In contrast with mouse thymocytes, mouse ES cells contain greater ranges of complete genomic H3K4me3 and have larger H3K4me3 occupancy on the promoter of the pluripotent gene Oct4 forty six In agreement with this, global decreases in H3K4me3 levels occur during retinoic acid (RA)-induced differentiation of mouse ES cells 47 In addition, there are dynamic changes in H3K4me3 profiles at specific units of genes throughout ES cell differentiation.
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